| 应用 | N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine has been used:· in the treatment of human embryonic kidney (HEK293T) cells for assessing its effect on the Jembrana disease virus (JDV) viral infectivity factor (Vif) functionality· in P19 embryonic carcinoma cells for chelation of zinc ions released during apoptosis · to evaluate its effect on lentiviral Vpx infection on human monocytic THP-1 cells |
| 生化机理 | N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling.[1] In microglia pretreated with zinc, TPEN inhibits the interleukin 6 secretion and nitric oxide synthase (iNOS) mRNA expression.[2] It induces damage on DNA structure by activating ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) signaling in human colon cancer cells. TPEN是一种可透过膜的锌螯合剂；可降低细胞内锌水平并诱导细胞凋亡（即细胞收缩和凋亡小体的形成、DNA片段化和形成典型的DNA梯状带）。 |
| 别名 | ;TPEN;TPEDA |
N,N,N',N'-四(2-吡啶甲基)乙二胺
N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine （订货以英文为准）
编号：N159625
CAS号：16858-02-9
分子式：C26H28N6
分子量：424.55
| 产品名称 | N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine |
| 中文名称 | N,N,N',N'-四(2-吡啶甲基)乙二胺 |
| CAS号 | 16858-02-9 |
| MDL编码 | MFCD00036918 |
| 分子式（M.F.） | C26H28N6 |
| 分子量（M.W.） | 424.55 |
| 储存条件 | -20°C储存 |
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