| 溶解性 | Soluble in DMSO (65 mg/ml at 25 °C), ethanol (52 mg/ml at 25 °C), DMF (~16.5 mg/ml), PBS (pH 7.2, ~0.04 mg/ml), and water (<1 mg/ml at 25 °C). |
| 应用 | A highly potent PPARα agonist |
| 产品介绍 | WY-14643 (Pirinixic Acid)是一种有效的过氧化物酶体增殖子和PPARα激活剂，EC50为1.5 μM。 |
| 备注 | WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM. |
| 生化机理 | WY 14643 is a highly potent PPARα agonist. Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are hormone receptors that induce the gene acyl-Coa and modulate the peroxisomal beta oxidation of fatty acids. WY 14643 has been shown to inhibit TNF-α-induced VCAM-1, and reduce TNF-α and IL-1β. Studies indicate that WY 14643 inhibits proliferation of trophoblast cells at lower concentrations than clofibric acid, and decreases the levels of S-100 β chain (S100B) protein. |
| 别名 | [4-氯-6-(2,3-茬胺基)-2-嘧啶硫代]乙酸;匹立尼酸;4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid;Pirinixic acid;WY 14643 |
[4-氯-6-(2,3-茬胺基)-2-嘧啶硫代]乙酸
WY-14643 (Pirinixic Acid) （订货以英文为准）
编号：W129766
CAS号：50892-23-4
分子式：C14H14CLN3O2S
分子量：323.80
| 产品名称 | WY-14643 (Pirinixic Acid) |
| 中文名称 | [4-氯-6-(2,3-茬胺基)-2-嘧啶硫代]乙酸 |
| CAS号 | 50892-23-4 |
| 分子式（M.F.） | C14H14CLN3O2S |
| 分子量（M.W.） | 323.80 |
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