化学信息：
| 化学名 | 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione |
| 简称 | Cycloheximide |
| 别名 | Naramycin A; Actidione; Cicloheximide |
| 中文名 | 放线菌酮 |
| 化学式 | C15H23NO4 |
| 分子量 | 281.35 |
| CAS号 | 66-81-9 |
| 纯度 | ≥98% |
| 溶剂/溶解度 | Water <1mg/ml; DMSO 32mg/ml; Ethanol <1mg/ml |
| 溶液配制 | 5mg加入1.78ml DMSO，或者每2.81mg加入1ml DMSO，配制成10mM溶液。SC0353-10mM用DMSO配制。 |
生物信息：
| 产品描述 | Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5nM. | ||||
| 信号通路 | Translational Control | ||||
| 靶点 | Protein synthesis | RNA synthesis | － | － | － |
| IC50 | 532.5nM | 2.88μM | － | － | － |
| 体外研究 | Cycloheximide is a highly effective antibiotic with activity against mold, yeast, and phytopathogenic fungi, with lower activity against bacteria. It has been reported to inhibit the synthesis of both proteins and macromolecules, as well as affect apoptosis in eukaryotes. Inhibition of protein synthesis is believed to be mediated through DNA translation arrest, as demonstrated in rat thymocytes. Cycloheximide has also been reported to inhibit FKBP12 (peptidylprolylisomerase hFKBP12, PPIase hFKBP12) via competitive inhibition. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome) thus blocking translational elongation. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
| 特征 | N/A | ||||
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
| 酶活性检测实验 | |
| 方法 | N/A |
| 细胞实验 | |
| 细胞系 | N/A |
| 浓度 | N/A |
| 处理时间 | N/A |
| 方法 | N/A |
| 动物实验 | |
| 动物模型 | N/A |
| 配制 | N/A |
| 剂量 | N/A |
| 给药方式 | N/A |
参考文献：
Schneider-Poetsch T, et al. Nat Chem Biol. 2010, Mar, 6(3), 209-217.
Fischer-Posovszky P, Keuper M, Nagel S, et al. Experimental cell research. 2011, 317(15), 2200-2209.
Park W S, Sung D K, Kang S, et al. Journal of Korean medical science. 2006, 21(3), 490-494.
包装清单：
| 产品编号 | 产品名称 | 包装 |
| SC0353-10mM | Cycloheximide (Protein synthesis抑制剂) | 10mM×0.2ml |
| SC0353-5mg | Cycloheximide (Protein synthesis抑制剂) | 5mg |
| SC0353-25mg | Cycloheximide (Protein synthesis抑制剂) | 25mg |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
党沛 
