化学信息:
化学名 | 3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one | |
简称 | Tedizolid | |
别名 |
TR-700, DA-7157, Torezolid, TR 700, DA 7157 |
|
中文名 | 特地唑胺 | |
化学式 | C17H15FN6O3 | |
分子量 | 370.34 | |
CAS号 | 856866-72-3 | |
纯度 | 98% | |
溶剂/溶解度 |
Water<1mg/ml; DMSO4mg/ml; Ethanol<1mg/ml |
|
溶液配制 | 5mg加入1.35ml DMSO,或者每3.7mg加入1ml DMSO,配制成10mM溶液。SC3265-10mM用DMSO配制。 |
生物信息:
产品描述 | Torezolid (TR-701; tedizolid) is a novel oxazolidinone for gram-positive infections. | ||||
信号通路 | Anti-infection | ||||
靶点 | MAO-A | MAO-B | - | - | - |
IC50 | 8.7μM | 5.7μM | - | - | - |
体外研究 | Tedizolid was reversible inhibitors of human MAO-A and MAO-B; the 50% inhibitory concentration (IC50) for tedizolid was 8.7μM for MAO-A and 5.7μM for MAO-B. Tedizolid phosphate was negative in the mouse head twitch model of serotonergic activity. Two randomized placebo-controlled crossover clinical studies assessed the potential of 200mg/day tedizolid phosphate (at steady state) to enhance pressor responses to coadministered oral tyramine or pseudoephedrine. Sensitivity to tyramine was determined by comparing the concentration of tyramine required to elicit a ≥30mmHg increase in systolic blood pressure (TYR30) when administered with placebo versus tedizolid phosphate. The geometric mean tyramine sensitivity ratio (placebo TYR30/tedizolid phosphate TYR30) was 1.33; a ratio of ≥2 is considered clinically relevant. In the pseudoephedrine study, mean maximum systolic blood pressure was not significantly different when pseudoephedrine was coadministered with tedizolid phosphate versus placebo. | ||||
体内研究 | N/A | ||||
临床实验 | N/A | ||||
特征 | N/A |
相关实验数据(此数据来自于公开文献,碧云天并不保证其有效性):
酶活性检测实验 | |
方法 | N/A |
细胞实验 | |
细胞系 | N/A |
浓度 | N/A |
处理时间 | N/A |
方法 | N/A |
动物实验 | |
动物模型 | N/A |
配制 | N/A |
剂量 | N/A |
给药方式 | N/A |
参考文献:
包装清单:
1. Keel RA, Tessier PR, Crandon JL, Nicolau DP. Antimicrob Agents Chemother. 2012 Aug, 56(8), 4403-7.
2. Sahre M, Sabarinath S, Grant M, Seubert C, Deanda C, Prokocimer P, Derendorf H. Int J Antimicrob Agents. 2012 Jul, 40(1), 51-4.
3. Kanafani ZA, Corey GR. Expert Opin Investig Drugs. 2012 Apr, 21(4), 515-22.
产品编号 | 产品名称 | 包装 |
SC3265-10mM | Tedizolid (MAO-A抑制剂) | 10mM×0.2ml |
SC3265-5mg | Tedizolid (MAO-A抑制剂) | 5mg |
SC3265-25mg | Tedizolid (MAO-A抑制剂) | 25mg |
— | 说明书 | 1份 |
保存条件:
-20℃保存,至少一年有效。5mg和25mg包装也可室温保存,至少6个月有效。如果溶于非DMSO溶剂,建议分装后-80℃保存,预计6个月内有效。
注意事项:
本产品对人体有刺激性,操作时请小心,并注意适当防护以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。