AS-605240,PI3Kγ抑制剂

AS-605240 (订货以英文为准)

编号:A127765
CAS号:648450-29-7
分子式:C12H7N3O2S
分子量:257.27
货号 品牌 包装 目录价 您的价格 库存 数量 购买
A127765-5mg 阿拉丁 5mg ¥350.90
A127765-100mg 阿拉丁 100mg ¥2677.90
A127765-25mg 阿拉丁 25mg ¥1132.90
产品名称 AS-605240
中文名称 AS-605240,PI3Kγ抑制剂
CAS号 648450-29-7
MDL编码 MFCD11100415
分子式(M.F.) C12H7N3O2S
分子量(M.W.) 257.27
储存条件 -20°C储存
溶解性DMSO 0.4 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
产品介绍AS-605240是PI3Kγ选择性抑制剂,IC50为8 nM。比对PI3Kδ,PI3Kβ和PI3Kα的抑制性强30倍和7.5倍。
备注AS-605240 selectively inhibits PI3Kγ with IC50 of 8 nM, over 30-fold and 7.5-fold more selective for PI3Kγ than PI3Kδ/β and PI3Kα, respectively.
生化机理AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). AS-605240 displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. AS-605240 suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.
别名AS605240; AS 605240; 5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮;;AS605240; AS 605240;5-(6-quinoxalinylmethylene)-2,4-thiazolidinedione; pi 3-k|? inhibitor
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