GW788388,TGF-βRI的有效抑制剂

GW788388 (订货以英文为准)

编号:G125999
CAS号:452342-67-5
分子式:C25H23N5O2
分子量:425.48
货号 品牌 包装 目录价 您的价格 库存 数量 购买
G125999-10mg 阿拉丁 10mg ¥305.90
G125999-5mg 阿拉丁 5mg ¥300.90
G125999-250mg 阿拉丁 250mg ¥4325.90
G125999-50mg 阿拉丁 50mg ¥1220.90
产品名称 GW788388
中文名称 GW788388,TGF-βRI的有效抑制剂
CAS号 452342-67-5
MDL编码 MFCD16038936
分子式(M.F.) C25H23N5O2
分子量(M.W.) 425.48
储存条件 -20°C储存
溶解性DMSO 33 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
产品介绍GW788388是一种有效的,选择性的ALK5抑制剂,IC50为18 nM,也抑制其他TGF-βI型和II型受体激酶活性,但不抑制BMP II型受体
备注GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
生化机理GW788388 is a potent selective inhibitor of TGF-beta type I receptor [activin receptor-like kinase 5 (ALK5)]. GW788388 is orally available with a half-life of approximately 4 hours. GW788388 is useful in treatment of renal fibrosis.
别名GW 788388; 4-[4-[3-(吡啶-2-基)-1H-吡唑-4-基]吡啶-2-基]-N-(四氢吡喃-4-基)苯甲酰胺;GW 788388;GW-788388;4-[4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl]-N-(tetrahydropyran-4-yl)benzamide
搜索质检报告(COA)
搜索MSDS
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