| 溶解性 | 25°C: DMSO 67 mg/mL; Water <1 mg/mL; Ethanol 7 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Vinblastine抑制微管形成，抑制nAChR活性，IC50为8.9 μM。 |
| 备注 | Vinblastine inhibits microtubule formation and supresses nAChR activity with IC50 of 8.9 μM. |
| 生化机理 | Vinblastine does not interfere with phrenic nerve stimulation of rat diaphragm musculature in concentrations up to 200 microM. However, in relatively high doses, vinblastine (10-200 microM) produces an increase in baseline tension of diaphragm muscle. This effect is concentration related (EC50, approximately 88 microM), reversible, and independent of phrenic nerve stimulation. The elevation in baseline tension is unaffected by nAChR blockade via d-tubocurarine, but is dependent upon the presence of extracellular calcium. In human Burkitt lymphoma CA46 cells, vinblastine (IC50 values, 1.0 nM). It binds tubulin, thereby inhibiting the assembly of microtubules.It is used to treat certain kinds of cancer, including Hodgkin |
| 别名 | Vincaleukoblastine, Velban, Velsar;1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid,4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-,meth;长春花碱;Vincaleukoblastine, Velban, Velsar;1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid,4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-,meth |
长春花碱
Vinblastine （订货以英文为准）
编号：V127032
CAS号：865-21-4
分子式：C46H58N4O9
分子量：810.97
| 产品名称 | Vinblastine |
| 中文名称 | 长春花碱 |
| CAS号 | 865-21-4 |
| 分子式（M.F.） | C46H58N4O9 |
| 分子量（M.W.） | 810.97 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H319 |
| 警示性声明 | P305 + P351 + P338 |
| WGK德国 | 3 |
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