| 溶解性 | DMSO 114 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A potent, selective, small-molecule tyrosine kinase HER2 inhibitor |
| 产品介绍 | 这个产品是ARRY-380的类似物, ARRY-380是高活性HER2抑制剂，IC50为8 nM，对剪切型p95-HER2有相同的抑制性，比对EGFR的抑制性高500倍。 |
| 备注 | ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR. Phase 1. |
| 生化机理 | ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. |
| 别名 | ARRY380; ARRY 380; 6-[5-[[[2-(甲磺酰基)乙基]氨基]甲基]-2-呋喃基]-N-[3-甲基-4-([1,2,4]三唑并[1,5-a]吡啶-7-氧基)苯基]-4-氨基喹唑啉;ARRY380;ARRY 380; 6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine |
ARRY-380
ARRY-380 （订货以英文为准）
编号：A126334
CAS号：937265-83-3
分子式：C29H27N7O4S
分子量：569.63
| 产品名称 | ARRY-380 |
| 中文名称 | ARRY-380 |
| CAS号 | 937265-83-3 |
| 分子式（M.F.） | C29H27N7O4S |
| 分子量（M.W.） | 569.63 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H315-H319-H335 |
| 警示性声明 | P261-P305 + P351 + P338 |
| 个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
| WGK德国 | 3 |
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