| 熔点 | 170-175°C |
| 敏感性 | 对光线和湿度敏感 |
| 溶解性 | Soluble in phosphate buffered saline (1 mg/ml), ethanol, ethyl acetate, lower alcohols, and acetone. Insoluble in water. |
| 存贮条件 | 储存温度-20°C ，充氩保存 |
| 密度 | 1.4800 |
| 应用 | A polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA;DNA binding fluorescent dye. Until 2000 it was used to reduce high levels of plasma calcium; Used as an antineoplastic agent |
| 产品介绍 | Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-α and Fas-ligand induced apoptosis. As a DNA binding transcriptional inhibitor, mithramycin A binds to GC rich sequences located in the minor groove of DNA and is noted to be reversible and Mg2+ dependent. Additionally reported to a block transcriptional activation of the SV40 promoter via competitive binding against Sp1 transcription factor to GC rich areas in the early promoter. Mithramycin A is noted to supress TNF-α induced expression of fractalkine (CX3CL1) mRNA in a dose-dependent manner and to act as an effective differentiation agent of HL60 promyelocytic leukemia cells |
| 生化机理 | Anticancer antibiotic. Inhibits transcription and protein synthesis. Binds to DNA in native chromatin. Substrate of Pgp in MDR phenotypes. |
| 别名 | 普卡酶素 ;光辉酶素;光神霉素;普芳拉星;金霉酸;Mithramycin A;Mithramycin;Aureolic acid;Mithramycin A |
普卡酶素
Plicamycin （订货以英文为准）
编号：P113149
CAS号：18378-89-7
分子式：C52H76O24
分子量：1085.15
| 产品名称 | Plicamycin |
| 中文名称 | 普卡酶素 |
| CAS号 | 18378-89-7 |
| MDL编码 | MFCD00135618 |
| 分子式（M.F.） | C52H76O24 |
| 分子量（M.W.） | 1085.15 |
| 储存条件 | -20°C储存;充氩 |
| 个人防护设备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
| WGK德国 | 3 |
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