| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | PND-1186是高活性FAK抑制剂，IC50为1.5 nM。 |
| 生化机理 | PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397. PND-1186 did not alter c Src or p130Cas tyrosine phosphorylation in adherent cells, yet functioned to restrain cell movement. Notably, 1.0 μM PND-1186 (>5-fold above IC50) had limited effects on cell proliferation. However, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 μM PND-1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis. |
| 别名 | VS-4718；PND 1186;PND1186;;SR 2516;SR2516；SR-2516；2-[[2-[[2-Methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide; |
PND-1186,FAK抑制剂
PND-1186 （订货以英文为准）
编号：P126394
CAS号：1061353-68-1
分子式：C25H26F3N5O3
分子量：501.50
| 产品名称 | PND-1186 |
| 中文名称 | PND-1186,FAK抑制剂 |
| CAS号 | 1061353-68-1 |
| 分子式（M.F.） | C25H26F3N5O3 |
| 分子量（M.W.） | 501.50 |
| 储存条件 | -20°C储存 |
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