| 溶解性 | Soluble in DMSO (20 mg/ml), DMF (30 mg/ml), ethanol (10 mg/ml), and 1:1 solution DMF:PBS(pH 7.2) (0.5 mg/ml). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | An inhibitor of the transcription factor NFκB. |
| 产品介绍 | QNZ (EVP4593)有效抑制NF-κB激活和TNF-α产生，IC50分别为11 nM和7 nM。 |
| 备注 | QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively. |
| 生化机理 | QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling. Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection. Research results suggest that QNZ fully blocks the increase in K currents in rat sensory neurons. QNZ has been used to study colorectal cancer and Schwann cell functioning. |
| 别名 | N4-[2-(4-苯氧基苯基)乙基]-4,6-喹唑啉二胺;EVP4593; EVP 4593; EVP-4593;EVP4593;EVP 4593;EVP-4593；4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine; N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine;6-Amino-4-[2-(4-phenoxyphenyl)ethylamino]quinazoline |
QNZ (EVP4593),NF-kB抑制剂
QNZ (EVP4593) （订货以英文为准）
编号：Q125550
CAS号：545380-34-5
分子式：C22H20N4O
分子量：356.42
| 产品名称 | QNZ (EVP4593) |
| 中文名称 | QNZ (EVP4593),NF-kB抑制剂 |
| CAS号 | 545380-34-5 |
| MDL编码 | MFCD06411436 |
| 分子式（M.F.） | C22H20N4O |
| 分子量（M.W.） | 356.42 |
| 储存条件 | -20°C储存;充氩 |
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