| 溶解性 | DMSO 76 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A porcupine homolog - Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase |
| 产品介绍 | Wnt-C59(C59)是高活性Wnt信号转导拮抗剂，IC50为74 pM。 |
| 生化机理 | C59 inhibits PORCN activity in vitro at nanomolar concentrations, as assessed by inhibition of Wnt palmitoylation, Wnt interaction with the carrier protein Wntless/WLS, Wnt secretion, and Wnt activation of β-catenin reporter activity . Wnt-C59 was used at 0.1-0.2 μM to completely block Wnt protein secretion. When used at 0.5 μM, it can be used functionally replace the Dkk protein in many assay conditions. |
| 别名 | Wnt C59;C59; 4-(2-甲基-4-吡啶基)-N-(4-(3-吡啶基)苯基)苯乙酰胺;;Wnt C59;C59; 4-(2-methyl-4-pyridinyl)-n-(4-(3-pyridinyl)phenyl)benzeneacetamide |
Wnt-C59(C59),细胞渗透性Wnt信号通路抑制剂
Wnt-C59 (C59) （订货以英文为准）
编号：W125232
CAS号：1243243-89-1
分子式：C25H21N3O
分子量：379.45
| 产品名称 | Wnt-C59 (C59) |
| 中文名称 | Wnt-C59(C59),细胞渗透性Wnt信号通路抑制剂 |
| CAS号 | 1243243-89-1 |
| 分子式（M.F.） | C25H21N3O |
| 分子量（M.W.） | 379.45 |
| 储存条件 | -20°C储存 |
| 个人防护设备 | dust mask type N95 (US)， Eyeshields， Gloves |
| WGK德国 | 3 |
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