| 溶解性 | DMSO 110 mg/mL Water <1 mg/mL Ethanol 54 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1. |
| 生化机理 | TAK-285 is a novel dual HER2 and EGFR inhibitor with IC50 of 17 nM and 23 nM, respectively. A Phase I study of TAK-285 in patients with advanced cancer has been completed. TAK-285 is a novel, orally active, dual HER2/EGFR inhibitor with antitumor activity in mouse xenograft models, including breast, gastric, lung, and colon cancer. |
| 别名 | N-(2-(4-(3-chloro-4-(3-(trifluoromethyl)phenoxy)phenylamino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide;N-(2-(4-(3-chloro-4-(3-(trifluoromethyl)phenoxy)phenylamino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide |
TAK-285
TAK-285 （订货以英文为准）
编号：T126234
CAS号：871026-44-7
分子式：C26H25CLF3N5O3
分子量：547.96
| 产品名称 | TAK-285 |
| 中文名称 | TAK-285 |
| CAS号 | 871026-44-7 |
| 分子式（M.F.） | C26H25CLF3N5O3 |
| 分子量（M.W.） | 547.96 |
| 储存条件 | -20°C储存 |
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