| 溶解性 | Soluble in DMSO (25 mg/mL warming), ethanol (25 mg/mL warming), methanol, and chloroform. Insoluble in water. |
| 应用 | A Met inhibitor effective against various cell lines |
| 产品介绍 | PF-2341066 shows inhibition of Met phosphorylation in mIMCD3 mouse of MDCK canine epithelial cells with an IC50 of 5 nM and 20 nM, respectively, as well as NCI-H69 and HOP92 cells, with an IC50 of 13 nM and 16 nM, respectively. PF-2341066 shows a near-equivalent IC50 of 24 nM against the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncogenic fusion varient of the ALK RTK expressed by the KARPAS299 human anaplastic large-cell lymphoma (ALCL) cell line. PF-2341066 supresses human GTL-16 gastric carcinoma cell growth with an IC50 of 9.7 nM. PF-2341066 induces apoptosis in GTL-16 cells with an IC5050 of 30 nM. |
| 别名 | 克里唑替尼;3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺;Xalkori;(R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine |
克唑替尼
Crizotinib （订货以英文为准）
编号：C137735
CAS号：877399-52-5
分子式：C21H22CL2FN5O
分子量：450.34
| 产品名称 | Crizotinib |
| 中文名称 | 克唑替尼 |
| CAS号 | 877399-52-5 |
| 分子式（M.F.） | C21H22CL2FN5O |
| 分子量（M.W.） | 450.34 |
| 储存条件 | 2-8°C储存 |
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