| 溶解性 | DMSO 78 mg/mL Water <1 mg/mL Ethanol 10 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | CTEP is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors. |
| 生化机理 | The metabotropic glutamate receptor 5 (mGlu5) is a glutamate-activated class C G protein-coupled receptor widely expressed in the central nervous system and clinically investigated as a drug target for a range of indications, including depression, Parkinson's disease, and fragile X syndrome. CTEP is a novel, potent, selective and orally bioavailable allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. CTEP binds mGlu5 with low nanomolar affinity and shows >1000-fold selectivity when tested against 103 targets, including all known mGlu receptors. In animal studies CTEP was found to have a high oral bioavailability and a long duration of action, lasting 18 hours after a single dose, giving it considerably improved properties over older mGluR5 antagonists such as MPEP and fenobam. |
CTEP (RO4956371),mGlu5 受体别构拮抗剂
CTEP (RO4956371) （订货以英文为准）
编号：C126237
CAS号：871362-31-1
分子式：C19H13CLF3N3O
分子量：391.77
| 产品名称 | CTEP (RO4956371) |
| 中文名称 | CTEP (RO4956371),mGlu5 受体别构拮抗剂 |
| CAS号 | 871362-31-1 |
| MDL编码 | MFCD22665726 |
| 分子式（M.F.） | C19H13CLF3N3O |
| 分子量（M.W.） | 391.77 |
| 储存条件 | 避光;-20°C储存;干燥 |
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