溶解性 | Soluble in DMSO (64 mg/mL at 25 °C), water (<1 mg/mL at 25 °C), and ethanol (2 mg/mL at 25 °C). |
存贮条件 | 储存温度 2-8°C |
应用 | An inhibitor of c-Abl, PI 3-kinase, PDGFR, Hck, FRAP, Flk-1, SRC, and DNA-PK. |
产品介绍 | PP121是一种作用于PDGFR, Hck, mTOR, VEGFR2, Src和Abl的多靶点抑制剂,IC50分别为2 nM, 8 nM, 10 nM, 12 nM, 14 nM和18 nM,也抑制DNA-PK,IC50为60 nM。 |
备注 | PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM. |
生化机理 | PP121 has been shown to be an inhibitor of tyrosine and phosphoinositide kinases. PP121 inhibits c-Abl (IC50 of 18 nM), PI 3-kinase (IC50 of < 0.06 μM), PDGFR (IC50 of 2 nM), Hck (IC50 of 8 nM), FRAP (IC50 of 10 nM), Flk-1 (IC50 of 12 nM), SRC (IC50 of 14 nM), and DNA-PK (IC50 of < 0.06 μM). PP121 does not affect other serine-threonine protein kinases. PP-121 potently inhibits the proliferation of a subset of tumor cell lines by direct inhibition of PI 3-kinase and FRAP. |
别名 | PP 121; PP-121;1-环戊基-3-(1H-吡咯并[2,3-b]吡啶-5-基)-1H-吡唑并[3,4-d]嘧啶-4-胺;PP 121;PP-121; 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
PP121,酪氨酸和磷酸肌醇激酶的双重抑制剂
PP121 (订货以英文为准)
编号:P126419
CAS号:1092788-83-4
分子式:C17H17N7
分子量:319.36
产品名称 | PP121 |
中文名称 | PP121,酪氨酸和磷酸肌醇激酶的双重抑制剂 |
CAS号 | 1092788-83-4 |
MDL编码 | MFCD12912434 |
分子式(M.F.) | C17H17N7 |
分子量(M.W.) | 319.36 |
储存条件 | 2-8°C储存 |
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