| 溶解性 | Soluble in DMSO (74 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (3 mg/ml at 25 °C). |
| 存贮条件 | 储存温度-20°C |
| 应用 | An ATP-competitive inhibitor against VEGFR-2, Flk-1, VEGFR-1 and FGFR-1 |
| 产品介绍 | Brivanib (BMS-540215)是一种ATP竞争性的VEGFR2抑制剂，IC50为25 nM，对VEGFR-1和FGFR-1抑制作用适中，但比作用于PDGFR-β效果强240多倍。 |
| 备注 | Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3. |
| 生化机理 | Brivanib is an ATP-competitive inhibitor against human VEGFR-2 and mouse Flk-1 with IC50 of 25 nM and 89 nM, respectively. Brivanib also inhibits VEGFR-1 and FGFR-1 with IC50 of 0.38 and 0.148 μM. Brivanib displays antitumor activities in H3396 xenograft. This compound completely inhibits the tumor growth, with TGI of 85% and 97%, respectively. |
| 别名 | 1-[[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氧基]-2-丙醇; 酪氨酸激酶抑制剂;BMS-540215; BMS540215; BMS 540215;(2R)-1-[4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4 ]triazin-6-yloxy]propanol |
Brivanib (BMS-540215),VEGFR2抑制剂
Brivanib (BMS-540215) （订货以英文为准）
编号：B127317
CAS号：649735-46-6
分子式：C19H19FN4O3
分子量：370.39
| 产品名称 | Brivanib (BMS-540215) |
| 中文名称 | Brivanib (BMS-540215),VEGFR2抑制剂 |
| CAS号 | 649735-46-6 |
| 分子式（M.F.） | C19H19FN4O3 |
| 分子量（M.W.） | 370.39 |
| 储存条件 | -20°C储存 |
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