Tubastatin A盐酸盐

Tubastatin A HCl (订货以英文为准)

编号:T129677
CAS号:1310693-92-5
分子式:C20H22CLN3O2
分子量:371.86
货号 品牌 包装 目录价 您的价格 库存 数量 购买
T129677-50mg 阿拉丁 50mg ¥667.90
T129677-10mg 阿拉丁 10mg ¥378.90
T129677-250mg 阿拉丁 250mg ¥1691.90
T129677-5mg 阿拉丁 5mg ¥223.90
产品名称 Tubastatin A HCl
中文名称 Tubastatin A盐酸盐
CAS号 1310693-92-5
MDL编码 MFCD20488052
分子式(M.F.) C20H22CLN3O2
分子量(M.W.) 371.86
储存条件 -20°C储存
溶解性DMSO 74 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
应用An HDAC6 inhibitor
产品介绍Tubastatin A盐酸盐是HDAC6选择性抑制剂,IC50为15 nM,比对其它亚型的抑制性高1000倍(相对HDAC8是57倍)。
生化机理Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.
别名Tubastatin A 盐酸盐; N-羟基-4-[(1,2,3,4-四氢-2-甲基-5H-吡啶并[4,3-b]吲哚-5-基)甲基]苯甲酰胺盐酸盐;TSA HCl; Tubastatin A hydrochloride; N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride;N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
搜索质检报告(COA)
搜索MSDS
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