| 溶解性 | DMSO 115 mg/mL Water <1 mg/mL Ethanol 4 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively. |
| 生化机理 | TW-37 is Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). TW-37 inhibits the angiogenic potential of endothelial cells in vitro. TW-37 induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of Notch-1 and Jagged-1 in vitro and in vivo. |
| 别名 | 5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide;5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide |
TW-37,小分子BCL-2抑制剂
TW-37 （订货以英文为准）
编号：T127475
CAS号：877877-35-5
分子式：C33H35NO6S
分子量：573.71
| 产品名称 | TW-37 |
| 中文名称 | TW-37,小分子BCL-2抑制剂 |
| CAS号 | 877877-35-5 |
| 分子式（M.F.） | C33H35NO6S |
| 分子量（M.W.） | 573.71 |
| 储存条件 | -20°C储存 |
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