Reaxys-RN	471182
标识符号	https://www.aladdin-e.com/images/ghs/ghs02.jpg,https://www.aladdin-e.com/images/ghs/ghs05.jpg,https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词	Danger
危害声明	H226,H302,H315,H318,.H335
警示性声明	P261,P280,P305+P351+P338
个人防护设备	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
WGK德国	2
闪点（摄氏）	51°C
风险声明 (欧洲)	R10;R22;R37/38;R41
安全声明（欧洲）	S26;S39
危害码（欧洲）	Xn

Background:	This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues
Applications:	WB, IHC, IF
Name of antibody:	MDM2 (phospho-Ser166)
Immunogen:	Synthetic peptide of human MDM2 (phospho-Ser166)
Full name:	MDM2 oncogene, E3 ubiquitin protein ligase (phospho-Ser166)
Synonyms：	HDMX; hdm2; ACTFS
SwissProt:	Q00987
IHC positive control:	Human breast carcinoma
IHC Recommend dilution:	50-100
WB Predicted band size:	90 kDa
WB Positive control:	293 cells treated with Hydroxyurea
WB Recommended dilution:	500-1000
IF Positive control:	Hela cells
IF Recommended dilution	100-200

沸点	164°C(lit.)
别名	;

3-(二甲氨基)吡咯烷

3-(Dimethylamino)pyrrolidine （订货以英文为准）