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ONX-0914 (PR-957)

ONX-0914 (PR-957) （订货以英文为准）

编号：O127572
CAS号：960374-59-8
分子式：C31H40N4O7
分子量：580.67
货号 品牌 包装 目录价 您的价格 库存 数量 购买
O127572-100mg 阿拉丁 100mg ¥5973.90
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O127572-25mg 阿拉丁 25mg ¥2316.90
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O127572-5mg 阿拉丁 5mg ¥667.90
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O127572-10mg 阿拉丁 10mg ¥1441.90
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O127572-50mg 阿拉丁 50mg ¥3604.90
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产品名称 ONX-0914 (PR-957)
中文名称 ONX-0914 (PR-957)
CAS号 960374-59-8
分子式（M.F.） C31H40N4O7
分子量（M.W.） 580.67
储存条件 -20°C储存
溶解性DMSO 100 mg/mL (172.21 mM);Water <1 mg/mL (<1 mM);Ethanol 100 mg/mL (172.21 mM)
存贮条件储存温度2-8℃
产品介绍ONX-0914 (PR-957)是一种有效的，选择性的immunoproteasome（免疫蛋白酶体）抑制剂，具有最低的交叉反应性。
备注ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome.
生化机理Description:IC50 Value: ~10 nM [1]ONX-0914 (PR-957) is a potent and selectiveimmunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome.in vitro: PR-957 blocked presentation of LMP7-specific, MHC-I-restricted antigens in vitro and in vivo. Selective inhibition of LMP7 by PR-957 blocked production of interleukin-23 (IL-23) by activated monocytes and interferon-gamma and IL-2 by T cells [1].in vivo:  In mouse models of rheumatoid arthritis and lupus, ONX-0914 treatment reverses signs of disease and results in reductions in cellular infiltration, cytokine production and autoantibody levels at well-tolerated doses. The maximum tolerated dose (MTD) of ONX-0914 in mice to be 30 mg/kg body weight. IFN-g release is inhibited by ~60% at LMP7-selective concentrations of ONX-0914 and by ~90% at higher concentrations. Production of IL-2 is also inhibited by ~50% [1].Toxicity: N/AClinical trial: N/A
别名;PR-957;ONX 0914;ONX0914;PR957;PR 957;N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide
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