| 溶解性 | DMSO 100 mg/mL (172.21 mM);Water <1 mg/mL (<1 mM);Ethanol 100 mg/mL (172.21 mM) |
| 存贮条件 | 储存温度2-8℃ |
| 产品介绍 | ONX-0914 (PR-957)是一种有效的，选择性的immunoproteasome（免疫蛋白酶体）抑制剂，具有最低的交叉反应性。 |
| 备注 | ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome. |
| 生化机理 | Description:IC50 Value: ~10 nM [1]ONX-0914 (PR-957) is a potent and selectiveimmunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome.in vitro: PR-957 blocked presentation of LMP7-specific, MHC-I-restricted antigens in vitro and in vivo. Selective inhibition of LMP7 by PR-957 blocked production of interleukin-23 (IL-23) by activated monocytes and interferon-gamma and IL-2 by T cells [1].in vivo: In mouse models of rheumatoid arthritis and lupus, ONX-0914 treatment reverses signs of disease and results in reductions in cellular infiltration, cytokine production and autoantibody levels at well-tolerated doses. The maximum tolerated dose (MTD) of ONX-0914 in mice to be 30 mg/kg body weight. IFN-g release is inhibited by ~60% at LMP7-selective concentrations of ONX-0914 and by ~90% at higher concentrations. Production of IL-2 is also inhibited by ~50% [1].Toxicity: N/AClinical trial: N/A |
| 别名 | ;PR-957;ONX 0914;ONX0914;PR957;PR 957;N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide |
ONX-0914 (PR-957)
ONX-0914 (PR-957) （订货以英文为准）
编号：O127572
CAS号：960374-59-8
| 产品名称 | ONX-0914 (PR-957) |
| 中文名称 | ONX-0914 (PR-957) |
| CAS号 | 960374-59-8 |
| 储存条件 | -20°C储存 |
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