2-吗啉代-8-苯基色酮

LY294002 (订货以英文为准)

编号:L124970
CAS号:154447-36-6
分子式:C19H18CLNO3
分子量:343.80
货号 品牌 包装 目录价 您的价格 库存 数量 购买
L124970-25mg 阿拉丁 25mg ¥226.90
L124970-250mg 阿拉丁 250mg ¥1053.90
L124970-500mg 阿拉丁 500mg ¥1750.90
L124970-10mg 阿拉丁 10mg ¥105.90
L124970-100mg 阿拉丁 100mg ¥587.90
L124970-50mg 阿拉丁 50mg ¥357.90
产品名称 LY294002
中文名称 2-吗啉代-8-苯基色酮
CAS号 154447-36-6
分子式(M.F.) C19H18CLNO3
分子量(M.W.) 343.80
储存条件 -20°C储存
溶解性Soluble in DMSO (25 mg/ml warm), ethanol (25 mg/ml warm), chloroform, water (< 50 ug/ml) at 25 °C, PBS pH 7.2 (< 50 ug/ml), DMF (~16 mg/ml ), and DMSO:PBS(1:1, pH 7.2) (~0.5 mg/ml ).
存贮条件储存温度2-8℃
应用A potent blocker of PI 3-kinase/Akt signaling.
产品介绍LY294002是第一个人工合成的PI3Kα/δ/β的抑制剂,IC50分别为0.5 μM/0.57 μM/0.97 μM,在溶液中比在Wortmannin中稳定,也能够抑制自噬体的形成。
备注LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation.
生化机理LY294002 is a potent inhibitor of PI 3-kinase, a protein in the phosphoinositide 3-kinase family of intercellular signal regulating enzymes. This compound is selective for PI 3-kinase p110 β (PI 3-Kβ) and PI 3-kinase p110 α (PI 3-Kα), although it will inhibit other PI 3 kinases at higher concentrations (IC50 = 310 nM and 730 nM for PI 3-Kβ and PI 3-Kα, respectively). The pathway associated with these receptors is implicated in cancer and diabetes, and LY294002 is an important tool for studying this relationship. Reports indicate that LY294002 encourages apoptosis in such cells by blocking the PI 3-kinase/Akt signaling pathway which has been strongly related to cancer survival and proliferation. LY 294002 is an inhibitor of Pim-1, PI 3-kinase p110 δ and PI 3-kinase p110 γ.
别名8-苯基-2-(吗啉-4-基)色原酮; 2-(4-吗啉基)-8-苯基-4H-1-苯并吡喃-4-酮;2-吗啉代-8-苯基-4-氧代-4H-1-苯并吡喃;NSC 697286; SF 1101; LY 294002; LY-294002;8-Phenyl-2-(morpholin-4-yl)chromen-4-one; 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one;2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one;2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran
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