熔点 | 221-222 °C |
溶解性 | Soluble in DMSO (5 mg/ml), and ethanol (100 mM). Insoluble in water. |
存贮条件 | 储存温度-20°C |
应用 | It was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain,and study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension. |
产品介绍 | Semaxanib (SU5416)是VEGFR(Flk-1/KDR)抑制剂,IC50为1.23 μM,比对PDGFRβ的抑制性高20倍,对EGFR,InsR和FGFR无活性。 |
生化机理 | VEGFR2 Kinase Inhibitor III is a cell-permeable ATP-competitive inhibitor of Flk-1 (VEGFR2/KDR, kinase insert domain receptor), which is the major growth factor for vascular endothelial cells. This receptor is a type III tyrosine kinase receptor that functions as the main mediator of VEGF-induced endothelial proliferation, survival, and migration. Studies suggest that VEGFR2 Kinase Inhibitor III also inhibits a variety of other receptors such as Met, Flt-3/Flk-2 (FLT-3 receptor tyrosine kinases), Ret, c-Kit, PDGFR, c-Abl and Arg (ABL), and ALK. In addition, VEGFR2 kinase inhibitor III regulates the signaling pathways used by oncogenic RET-transfected cells by regulating the extracellular signal regulated kinase (ERK) and JNK pathways. |
别名 | SU-5416; 1,3-二氢-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-2H-吲哚-2-酮;Semaxinib;SU-5416;VEGFR2 Kinase Inhibitor III; 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one |
塞马西尼
SU5416 (订货以英文为准)
编号:S125835
CAS号:204005-46-9
分子式:C15H14N2O
分子量:238.28
产品名称 | SU5416 |
中文名称 | 塞马西尼 |
CAS号 | 204005-46-9 |
分子式(M.F.) | C15H14N2O |
分子量(M.W.) | 238.28 |
储存条件 | -20°C储存 |
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