熔点 | 154-166 oC |
溶解性 | Soluble in DMSO (25 mg/mL) with warming; ethanol (1.7 mg/mL), and water (<1 mg/mL). |
存贮条件 | 储存温度-20°C |
应用 | A selective, potent, and irreversible ErbB2 and EGFR inhibitor. |
产品介绍 | Mubritinib (TAK 165)是一种有效的HER2/ErbB2抑制剂,IC50为6 nM;对EGFR, FGFR, PDGFR, JAK1, Src和Blk没有抑制活性。 |
备注 | Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk. |
生化机理 | TAK 165 is a potent Neu (HER2) and Cdc2 p34 inhibitor with IC50 of 6 nM and 0.2μM, respectively. TAK 165 also inhibits Cdk2 (p33cdk2) and Cdk5 (p33cdk5). TAK 165 displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. TAK 165 exhibits potent antiproliferative effects in Neu-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth. |
别名 | TAK 165;TAK165;木利替尼; 1-(4-(4-((2-((1E)-2-(4-(三氟甲基)苯基)乙烯基)-4-恶唑基)甲氧基)苯基)丁基)-1H-1,2,3-三氮唑;TAK 165; TAK165;1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole |
木利替尼
Mubritinib (TAK 165) (订货以英文为准)
编号:M129797
CAS号:366017-09-6
分子式:C25H23F3N4O2
分子量:468.47
产品名称 | Mubritinib (TAK 165) |
中文名称 | 木利替尼 |
CAS号 | 366017-09-6 |
分子式(M.F.) | C25H23F3N4O2 |
分子量(M.W.) | 468.47 |
储存条件 | -20°C储存 |
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