| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
| 生化机理 | Description:IC50 Value: 4.5 nM(In vitro inhibitory activity against Trypanosoma brucei rhodesiense) [4]DB289 (pafuramidine maleate; 2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) is a prodrug of DB75 (furamidine dihydrochloride; 2,5-bis(4-guanylphenyl)furan dihydrochloride), an aromatic dication related to pentamidine that has demonstrated good efficacy against African trypanosomiasis, Pneumocystis carinii pneumonia, and malaria, but lacks adequate oral availability. in vitro: The results of this investigation suggest that DB75 inhibits mitochondrial function. Yeast cells relying upon mitochondrial metabolism for energy production are especially sensitive to DB75 [1].in vivo: Clearance of DB289 approximated the liver plasma flow and its large volume of distribution was consistent with extensive tissue binding. Plasma protein binding of DB289 was 97 to 99% in four animal species and humans, but that of DB75 was noticeably less and mor |
| 别名 | ; |
帕呋拉定，抑制剂
Pafuramidine （订货以英文为准）
编号：P125387
CAS号：186953-56-0
分子式：C20H20N4O3
分子量：364.40
| 产品名称 | Pafuramidine |
| 中文名称 | 帕呋拉定，抑制剂 |
| CAS号 | 186953-56-0 |
| 分子式（M.F.） | C20H20N4O3 |
| 分子量（M.W.） | 364.40 |
| 储存条件 | -20°C储存 |
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