| 溶解性 | DMSO 113 mg/mL Water <1 mg/mL Ethanol 20 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | AC480 (BMS-599626)是 HER1和HER2选择性高效抑制剂，IC50分别为20 nM和30 nM，比针对VEGFR2，c-Kit，Lck，MET的抑制性强100倍以上。 |
| 备注 | AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1. |
| 生化机理 | BMS-599626 is a potent inhbitor of human epidermal growth factor receptors 1 and 2 (HER1 and HER2, IC50 = 20 and 30 nM, respectively). BMS599626 inhibits proliferation of several HER-expressing cancer cell lines, including HER2-overexpressing breast cancer lines, but does not affect the proliferation rate of HER-negative cancer cell lines |
| 别名 | [4-[[1-(3-氟苄基)-1H-吲唑-5-基]氨基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氨基甲酸(S)-吗啉-3-基甲酯;BMS-599626;BMS599626;AC480;BMS 599626;AC-480;AC 480； (3S)-3-Morpholinylmethyl-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-Carbamic acid |
AC480 (BMS-599626),HER1和HER2抑制剂
AC480 (BMS-599626) （订货以英文为准）
编号：B126145
CAS号：714971-09-2
分子式：C27H27FN8O3
分子量：530.55
| 产品名称 | AC480 (BMS-599626) |
| 中文名称 | AC480 (BMS-599626),HER1和HER2抑制剂 |
| CAS号 | 714971-09-2 |
| MDL编码 | MFCD10565678 |
| 分子式（M.F.） | C27H27FN8O3 |
| 分子量（M.W.） | 530.55 |
| 储存条件 | -20°C储存 |
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