| 熔点 | 145°C |
| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in ethanol (slightly), methanol, DMSO (100 mg/ml), DMF, and water (limited). |
| 存贮条件 | 储存温度 -20°C |
| 应用 | An indolocarbazole promoter of embryonic stem cell differentiation. |
| 产品介绍 | Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of Stauprimide |
| 生化机理 | Stauprimide is an enhancer stem cell differentiation into endoderm. In vitro differentiation of embryonic stem cells is of great interest to regenerative medicine, and current protocols are labor-intensive and expensive. Small molecules that induce or enhance differentiation are highly desired. High-content screening identified compounds that enhance endodermal differentiation in the presence of low levels of Activin A. Stauprimide increased definitive endodermal markers but not markers for visceral/parietal endoderm or mesoderm. Stauprimide-Stauprimide is an enhancer stem cell differentiation into endoderm. In vitro differentiation of embryonic stem cells is of great interest to regenerative medicine, and current protocols are labor-intensive and expensive. Small molecules that induce or enhance differentiation are highly desired. High-content screening identified compounds that enhance endodermal differentiation in the presence of low levels of Activin A. Stauprimide increased defin |
| 别名 | ;N-Benzoyl-7-oxostaurosporine |
Stauprimide,抑制剂
Stauprimide （订货以英文为准）
编号：S139814
CAS号：154589-96-5
分子式：C35H28N4O5
分子量：584.62
| 产品名称 | Stauprimide |
| 中文名称 | Stauprimide,抑制剂 |
| CAS号 | 154589-96-5 |
| 分子式（M.F.） | C35H28N4O5 |
| 分子量（M.W.） | 584.62 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs09.jpg |
| 信号词 | Warning |
| 危害声明 | H319,H332,H400 |
| 警示性声明 | P273,P305+P351+P338 |
| 个人防护设备 | Eyeshields, Faceshields, Gloves |
| WGK德国 | 2 |
| 风险声明 (欧洲) | R50/53 |
| 安全声明（欧洲） | S60;S61 |
| 危害码（欧洲） | N |
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