| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | AM095是LPA1受体拮抗剂，对人和小鼠LPA1的IC50分别为0.98和0.73 μM。 |
| 生化机理 | AM095 is an LPA? receptor antagonist with good oral exposure and antifibrotic activity in rodent models. In vitro, AM095 inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA? with IC?? values of 0.98 and 0.73 μM, respectively, and exhibited no LPA? agonism. In functional assays, AM095 inhibited LPA-driven chemotaxis of CHO cells overexpressing mouse LPA? (IC??= 778 nM) and human A2058 melanoma cells (IC?? = 233 nM). Another study showed that LPA/LPA? pathway inhibition has the potential to be an effective new therapeutic strategy for systemic sclerosis (SSc), and that LPA? is an attractive pharmacologic target in dermal fibrosis. |
| 别名 | 4'-(3-甲基-4-((((1R)-1-苯基乙氧基)羰基)氨基)-5-异恶唑基)联苯-4-乙酸钠盐;;AM 095;AM-095; 4'-(3-methyl-4-((((1r)-1-phenylethoxy)carbonyl)amino)-5-isoxazolyl)-(1,1'-biphenyl)-4-acetic acid sodium salt (1:1);am 095 |
AM095, LPA1 受体拮抗剂
AM095 （订货以英文为准）
编号：A126537
CAS号：1345614-59-6
分子式：C27H23N2NAO5
分子量：478.47
| 产品名称 | AM095 |
| 中文名称 | AM095, LPA1 受体拮抗剂 |
| CAS号 | 1345614-59-6 |
| 分子式（M.F.） | C27H23N2NAO5 |
| 分子量（M.W.） | 478.47 |
| 储存条件 | -20°C储存 |
搜索质检报告(COA)
搜索MSDS
相关产品
¥ 109.90
R749970-50ml
¥ 90.00
jx1325647-1支
党沛 
