| 沸点 | 586.8 °C |
| 旋光率 | 1.62 |
| 溶解性 | Soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C). |
| 应用 | An EGFR-tyrosine kinase inhibitor |
| 产品介绍 | Gefitinib (ZD1839)是一种EGFR抑制剂，作用于NR6wtEGFR和NR6W细胞中的Tyr1173，Tyr992，Tyr1173和Tyr992，IC50 分别为37 nM，37nM，26 nM和57 nM。 |
| 备注 | Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. |
| 生化机理 | Gefitinib is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and has been shown to increase phosphorylation of c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in HaCaT cells. Studies suggest that gefitinib can enhance keratinocyte apoptosis via an EGFR-independent JNK-activation pathway. Research indicates that gefitinib can induce apoptosis in several cell lines including, HaCaT cells, KG-1, P39, and primary CD34+ myeloblasts. |
| 别名 | ZD 1839;吉非替尼; N-(3-氯-4-氟苯基)-7-甲氧基-6-(3-吗啉-4-丙氧基)喹唑啉-4-胺;ZD 1839;Iressa;ZD-1839; ZD1839;N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine |
吉非替尼 (ZD1839)
Gefitinib (ZD1839) （订货以英文为准）
编号：G125799
CAS号：184475-35-2
分子式：C22H24CLFN4O3
分子量：446.90
| 产品名称 | Gefitinib (ZD1839) |
| 中文名称 | 吉非替尼 (ZD1839) |
| CAS号 | 184475-35-2 |
| 分子式（M.F.） | C22H24CLFN4O3 |
| 分子量（M.W.） | 446.90 |
| 储存条件 | 2-8°C储存 |
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