| 溶解性 | DMSO mg/mL Water mg/mL Ethanol mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. |
| 生化机理 | PF-543 is a novel cell-permeant inhibitor of SphK1. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling. |
| 别名 | 2-Pyrrolidinemethanol, 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-, (2R)-;2-Pyrrolidinemethanol, 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-, (2R)- |
PF-543
PF-543 （订货以英文为准）
编号：P125702
CAS号：1415562-82-1
分子式：C27H31NO4S
分子量：465.60
| 产品名称 | PF-543 |
| 中文名称 | PF-543 |
| CAS号 | 1415562-82-1 |
| 分子式（M.F.） | C27H31NO4S |
| 分子量（M.W.） | 465.60 |
| 储存条件 | -20°C储存 |
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