| 溶解性 | DMSO 46 mg/mL Water <1 mg/mL Ethanol 2 mg/mL |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A potent agonist at SR-1E and SR-1F. |
| 产品介绍 | BRL-54443是一种5-HT1E和5-HT1F受体激动剂，pKi分别为8.7和9.25，对5-HT1A， 5-HT1B， 5-HT1D受体具有弱的结合亲和力。 |
| 备注 | BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively, witha weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors. |
| 生化机理 | BRL 54443 is a potent SR-1E and SR-1F agonist (pEC50 values are 8.5 and 8.6 respectively). It induces SR-2A receptor-mediated mouse aortic contraction in vitro (pEC50 = 6.52). BRL 54443 displays > 30-fold selectivity over other serotonin and dopamine receptors (pKi values are 8.7, 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human SR-1E, SR-1F, SR-1A, SR-1B, SR-1D, SR-2A, SR-2B, SR-2C, SR-4, SR-7, D2 and D3 receptors respectively). |
| 别名 | 3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇;BRL54443; BRL 54443;BRL54443; BRL 54443;3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol;5-hydroxy-3-(1-methylpiperidin-4-yl)-1h-indole |
BRL-54443,5-HT 1E和5-HT 1F受体激动剂
BRL-54443 （订货以英文为准）
编号：B129734
CAS号：57477-39-1
分子式：C14H18N2O
分子量：230.31
| 产品名称 | BRL-54443 |
| 中文名称 | BRL-54443,5-HT 1E和5-HT 1F受体激动剂 |
| CAS号 | 57477-39-1 |
| 分子式（M.F.） | C14H18N2O |
| 分子量（M.W.） | 230.31 |
| 储存条件 | 2-8°C储存 |
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