富马酸氯马斯汀

Clemastine Fumarate (订货以英文为准)

编号:C129211
CAS号:14976-57-9
分子式:C21H26CLNO.C4H4O4
分子量:459.96
货号 品牌 包装 目录价 您的价格 库存 数量 购买
C129211-5g 阿拉丁 5g ¥2010.90
C129211-100mg 阿拉丁 100mg ¥146.90
C129211-500mg 阿拉丁 500mg ¥363.90
C129211-1g 阿拉丁 1g ¥562.90
C129211-250mg 阿拉丁 250mg ¥227.90
产品名称 Clemastine Fumarate
中文名称 富马酸氯马斯汀
CAS号 14976-57-9
MDL编码 MFCD00137486
分子式(M.F.) C21H26CLNO.C4H4O4
分子量(M.W.) 459.96
储存条件 2-8°C储存;充氩
熔点177-178 °C
敏感性对湿度敏感
溶解性Soluble in water (5 mM), methanol, DMSO (35 mg/ml), ethanol (3 mg/ml), and alcohol (slightly).
存贮条件储存温度 2-8°C
应用A selective histamine H1 antagonist
产品介绍Clemastine Fumarate是一种选择性组胺H1受体拮抗剂,IC50为3 nM。
备注Clemastine Fumarate (Clemastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.
生化机理Clemastine fumarate is a selective histamine H1 Receptor antagonist with IC50 of 3 nM. Clemastine Fumarate inhibits histamine induced rise in [Ca2+]i in HL-60 cells with an IC50 of 3 nM. Clemastine Fumarate significantly potentiates ATP-induced increase in [Ca2+]i in HEKhP2X7 cells not relying on histamine receptor blockage but on sensitizing P2X7 receptor
别名富马酸氯马斯汀; (R-(R*,R*))-1-甲基-2-(2-(1-(4-氯苯基)-1-苯乙氧基)乙基)-吡咯烷 (E)-2-丁烯二酸盐;Meclastine fumarate; Mecloprodine; Tavist;(+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt; (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt; 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt; 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt; Meclastine fumarate salt
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