熔点 | 177-178 °C |
敏感性 | 对湿度敏感 |
溶解性 | Soluble in water (5 mM), methanol, DMSO (35 mg/ml), ethanol (3 mg/ml), and alcohol (slightly). |
存贮条件 | 储存温度 2-8°C |
应用 | A selective histamine H1 antagonist |
产品介绍 | Clemastine Fumarate是一种选择性组胺H1受体拮抗剂,IC50为3 nM。 |
备注 | Clemastine Fumarate (Clemastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM. |
生化机理 | Clemastine fumarate is a selective histamine H1 Receptor antagonist with IC50 of 3 nM. Clemastine Fumarate inhibits histamine induced rise in [Ca2+]i in HL-60 cells with an IC50 of 3 nM. Clemastine Fumarate significantly potentiates ATP-induced increase in [Ca2+]i in HEKhP2X7 cells not relying on histamine receptor blockage but on sensitizing P2X7 receptor |
别名 | 富马酸氯马斯汀; (R-(R*,R*))-1-甲基-2-(2-(1-(4-氯苯基)-1-苯乙氧基)乙基)-吡咯烷 (E)-2-丁烯二酸盐;Meclastine fumarate; Mecloprodine; Tavist;(+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt; (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt; 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt; 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt; Meclastine fumarate salt |
富马酸氯马斯汀
Clemastine Fumarate (订货以英文为准)
编号:C129211
CAS号:14976-57-9
分子式:C21H26CLNO.C4H4O4
分子量:459.96
产品名称 | Clemastine Fumarate |
中文名称 | 富马酸氯马斯汀 |
CAS号 | 14976-57-9 |
MDL编码 | MFCD00137486 |
分子式(M.F.) | C21H26CLNO.C4H4O4 |
分子量(M.W.) | 459.96 |
储存条件 | 2-8°C储存;充氩 |
搜索质检报告(COA)
搜索MSDS
相关产品