| 敏感性 | 对光线和湿度敏感 |
| 溶解性 | Soluble in DMSO (heat briefly in boiling water bath) (25 mg/ml), dilute base (50 mM NaOH) (~5 mg/ml), and methanol (2 mg/ml). Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.1230 |
| 应用 | An inhibitor of sphingolipid biosynthesis with immunosuppressive properties. |
| 产品介绍 | Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model. |
| 生化机理 | Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. |
| 别名 | Myriocin;嗜热菌杀酵母素;ISP-1;2S,3R,4R,6E-2-氨基-3,4-二羟基-2-羟甲基L-14-氧-6-二十烯酸;(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid; ISP-I; Thermozymocidin |
多球壳菌素
Myriocin （订货以英文为准）
编号：M102400
CAS号：35891-70-4
分子式：C21H39NO6
分子量：401.54
| 产品名称 | Myriocin |
| 中文名称 | 多球壳菌素 |
| CAS号 | 35891-70-4 |
| MDL编码 | MFCD01632772 |
| 分子式（M.F.） | C21H39NO6 |
| 分子量（M.W.） | 401.54 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H315,H319,H360 |
| 警示性声明 | P201,P305+P351+P338,P308+P313 |
| 个人防护设备 | Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P2 (EN 143) respirator cartridges,type P3 (EN 143) respirator cartridges |
| WGK德国 | 3 |
| 风险声明 (欧洲) | R35;R61; |
| 安全声明（欧洲） | 53,26,36/37/39,45 |
| 危害码（欧洲） | T |
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