| 溶解性 | DMSO 13 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | MC1568 |
| 备注 | MC1568 is a selective HDAC inhibitor for HDAC1A with IC50 of 100 nM. It is 34-fold more selective for HDAC1A than HDAC1B. |
| 生化机理 | MC1568 is a class II (IIa) histone deacetylase (HDAC) inhibitor selective for HDAC4 and HDAC6 (IC50 = 220 nM). MC1568 exhibits tissue-selective inhibition between members of class II acetylases in vivo, particularly in skeletal muscle and the heart. MC1568 arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex. Recent research showed that class II-specific HDACis may constitute a novel therapeutic strategy for improving the treatment of cancer. |
| 别名 | (E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide;(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide |
MC1568,HDAC IIa类抑制剂
MC1568 （订货以英文为准）
编号：M127417
CAS号：852475-26-4
分子式：C17H15FN2O3
分子量：314.31
| 产品名称 | MC1568 |
| 中文名称 | MC1568,HDAC IIa类抑制剂 |
| CAS号 | 852475-26-4 |
| 分子式（M.F.） | C17H15FN2O3 |
| 分子量（M.W.） | 314.31 |
| 储存条件 | -20°C储存 |
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