| 溶解性 | DMSO >60 mg/mL Ethanol >60 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | LDE225 (NVP-LDE225,Erismodegib)是一种Smoothened(Smo)拮抗剂，抑制Hedgehog (Hh)信号通路，IC50分别为1.3 nM (小鼠)和2.5 nM(人)。 |
| 备注 | LDE225 (NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. Phase 3. |
| 生化机理 | LDE225 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. LDE225 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Inappropriate activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo. |
| 别名 | NVP-LDE225; rel-N-[6-[(2R,6S)-2,6-二甲基-4-吗啉基]-3-吡啶基]-2-甲基-4'-(三氟甲氧基)-[1,1'-联苯]-3-甲酰胺;LDE 225;NVP-LDE 225;Erismodegib;LDE-225; rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide |
LDE225 (NVP-LDE225,Erismodegib),Smoothened(Smo)拮抗剂
LDE225 (NVP-LDE225,Erismodegib) （订货以英文为准）
编号：L127562
CAS号：956697-53-3
分子式：C26H26F3N3O3
分子量：485.50
| 产品名称 | LDE225 (NVP-LDE225,Erismodegib) |
| 中文名称 | LDE225 (NVP-LDE225,Erismodegib),Smoothened(Smo)拮抗剂 |
| CAS号 | 956697-53-3 |
| 分子式（M.F.） | C26H26F3N3O3 |
| 分子量（M.W.） | 485.50 |
| 储存条件 | -20°C储存 |
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