| 沸点 | 507.06° C at 760 mmHg |
| 熔点 | 191.70° C |
| 折光率 | 1.71 |
| 溶解性 | DMSO 61 mg/mL Water <1 mg/mL Ethanol 61 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.4200 |
| 应用 | Human cisplatin-resistant gastric cancer cell line was treated with SKI-II to study the mechanism of reversion of multidrug resistance. |
| 产品介绍 | SKI II是一种合成的鞘氨醇激酶 (SK) 抑制剂, 抑制SK1和SK2, IC50值分别为78 μM和45 μM。 |
| 备注 | SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2. |
| 生化机理 | SKI II is a selective non-lipid inhibitor of SphK(sphingosine kinase) (IC50 = 0.5 μM); does not act at ATP-binding site. SKI II displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. SKI II induces apoptosis and inhibits prpliferation in several other tumor cell lines in vitro (IC50 = 0.9-4.6 μM). |
| 别名 | SKI-II;4-[[4-(4-氯苯基)-2-噻唑基]氨基]苯酚;Sphingosine Kinase Inhibitor 2;4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol |
SKI II,鞘氨醇激酶（SK1 / 2）抑制剂
SKI II （订货以英文为准）
编号：S129855
CAS号：312636-16-1
分子式：C15H11CLN2OS
分子量：302.78
| 产品名称 | SKI II |
| 中文名称 | SKI II,鞘氨醇激酶（SK1 / 2）抑制剂 |
| CAS号 | 312636-16-1 |
| MDL编码 | MFCD00733553 |
| 分子式（M.F.） | C15H11CLN2OS |
| 分子量（M.W.） | 302.78 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs02.jpg,https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Danger |
| 危害声明 | H225-H302 + H332-H319 |
| 警示性声明 | P210-P305 + P351 + P338 |
| WGK德国 | 2 |
| 闪点（摄氏） | 35.6 °F |
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