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乙酰地那林

CI-994 （订货以英文为准）

编号：C126432
CAS号：112522-64-2
分子式：C15H15N3O2
分子量：269.30
货号 品牌 包装 目录价 您的价格 库存 数量 购买
C126432-10mg 阿拉丁 10mg ¥195.90
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C126432-250mg 阿拉丁 250mg ¥2249.90
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C126432-50mg 阿拉丁 50mg ¥459.90
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产品名称 CI-994
中文名称 乙酰地那林
CAS号 112522-64-2
分子式（M.F.） C15H15N3O2
分子量（M.W.） 269.30
储存条件 -20°C储存
溶解性DMSO 54 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
应用An HDAC1, HDAC3, HDAC6, and HDAC8 inhibitor
产品介绍CI-994 (Tacedinaline)是抗癌化合物，能抑制HDAC1，IC50为0.57 μM，能促使细胞周期停滞于G1期。
备注CI-994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM and causes G1 cell cycle arrest. Phase 3.
生化机理Description: IC50 Value: 0.57 uM (For HDAC1,MTT assay) CI-994 (N-acetyldinaline) is a novel oral compound with a wide spectrum of antitumor activity in preclinical models, in vitro and in vivo. The mechanism of action may involve inhibition of histone deacetylation and cell cycle arrest[1]. in vitro: Different CI-994 concentrations were tested, ranging from 0.01 to 160 microM at 24, 48, and 72 h of treatment inA-549 (adenocarcinoma) and LX-1 (squamous cell carcinoma) ,with MTT assay. A concentration-dependent cell survival inhibition was observed, with an IC50 at 80 microM. The effect of CI-994, as demonstrated by recovery experiments, was cytostatic and seemed to be superimposable in both cell lines. Cytofluorimetric analysis to assess cell cycle perturbation and apoptosis was performed after 24 h of treatment, indicating a cell block with concomitant increase at G0/G1 phase, a reduction at S phase level at 20, 40, 80, and 160 microM, and apoptosis at the higher conce
别名PD-123654;4-乙酰氨基-N-(2-氨基苯基)苯甲酰胺;乙酰地那林;Acetyldinaline;Tacedinaline;PD 123654;Goe 5549;CI 994;CI994; 4-Acetylamino-N-(2′-aminophenyl)benzamide ;
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