| 溶解性 | DMSO 19 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | NSC319726是突变型p53R175再活化剂，能抑制表达p53R175的成纤维细胞增殖，IC50值为8nM，对野生型p53细胞无抑制作用。 |
| 生化机理 | NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells, shows 10- to 100-fold selectivity over the other hotspot p53 mutants. NSC319276 induces p53(R175)-mutant-dependent apoptosis. NSC319726 treatment induces a WT-like conformational change in the p53(R175) mutant protein that restores sequence-specific p53 transcription. The activity of NSC319726 depends on the zinc ion chelating properties of the compound as well as redox changes. |
| 别名 | NSC-319726；1-吖丁啶硫代羧酸[1-(2-吡啶基)亚乙基]酰肼;NSC-319726；1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide；[1-(2-Pyridinyl)ethylidene]hydrazide 1-Azetidinecarbothioic Acid |
NSC 319726,p53（R175）突变激活剂
NSC 319726 （订货以英文为准）
编号：N129966
CAS号：71555-25-4
分子式：C11H14N4S
分子量：234.32
| 产品名称 | NSC 319726 |
| 中文名称 | NSC 319726,p53（R175）突变激活剂 |
| CAS号 | 71555-25-4 |
| 分子式（M.F.） | C11H14N4S |
| 分子量（M.W.） | 234.32 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs09.jpg |
| 信号词 | Warning |
| 危害声明 | H302-H315-H319-H335-H400 |
| 警示性声明 | P261-P273-P305 + P351 + P338 |
| 个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
| WGK德国 | 3 |
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