| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 生化机理 | ARRY-520 is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 had low nanomolar antiproliferative activity in tumor cell lines. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis. |
ARRY-520
ARRY-520 （订货以英文为准）
编号：A126249
CAS号：885060-09-3
分子式：C20H22F2N4O2S
分子量：420.48
| 产品名称 | ARRY-520 |
| 中文名称 | ARRY-520 |
| CAS号 | 885060-09-3 |
| 分子式（M.F.） | C20H22F2N4O2S |
| 分子量（M.W.） | 420.48 |
| 储存条件 | -20°C储存 |
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