| 沸点 | ~575.2 °C at 760 mmHg |
| 熔点 | 213.39 °C |
| 折光率 | 1.70 |
| 溶解性 | DMSO ≥68mg/mL Water <1.2mg/mL Ethanol ≥4.7mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.5000 |
| 应用 | An inhibitor of JAK2 |
| 产品介绍 | AZD1480是ATP竞争性JAK2抑制剂，IC50为0.26 nM，对JAK1抑制性较弱。 |
| 备注 | AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1/2. |
| 生化机理 | AZD1480 demonstrated significant immunoregulatory effects by downregulating T-helper 2 cytokines and chemokines, including IL-13 and thymus- and activation-regulated chemokine, and the surface expression of the immunosuppressive programmed death ligands 1 and 2. Higher concentrations of AZD1480 (5μ) induced G2/M arrest and cell death by inhibiting Aurora kinases |
| 别名 | AZD1480;AZD 1480; 5-氯-N2-((1S)-1-(5-氟-2-嘧啶基)乙基)-N4-(5-甲基-1H-吡唑-3-基)-2,4-嘧啶二胺;;AZD1480;AZD 1480；5-chloro-n2-((1s)-1-(5-fluoro-2-pyrimidinyl)ethyl)-n4-(5-methyl-1h-pyrazol-3-yl)-2,4-pyrimidinediamine；(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine |
AZD1480,JAK2抑制剂
AZD1480 （订货以英文为准）
编号：A126326
CAS号：935666-88-9
分子式：C14H14CLFN8
分子量：348.77
| 产品名称 | AZD1480 |
| 中文名称 | AZD1480,JAK2抑制剂 |
| CAS号 | 935666-88-9 |
| 分子式（M.F.） | C14H14CLFN8 |
| 分子量（M.W.） | 348.77 |
| 储存条件 | -20°C储存 |
| 是否危化品 | 一般危化品 |
搜索质检报告(COA)
搜索MSDS
相关产品
¥ 500.00
sh6786-10mL
¥ 420.00
01484972-4L
¥ 1520.00
BWY0821011-1mL
¥ 259.00
sh24567-1个
党沛 
