| 溶解性 | DMSO 10 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | ZM 323881 is a potent and selective VEGFR2 inhibitor with IC50 of <2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2. |
| 生化机理 | Description: IC50 Value: <2nM( for VEGFR2) ZM323881 is a novel VEGF-R2 selective inhibitor, which has a potent and selective inhibitor of VEGF-R2 tyrosine kinase in vitro (IC(50) < 2 nM), compared with other receptor tyrosine kinases, including VEGF-R1 (IC(50) > 50 microM) [1]. M323881 inhibited activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor [2]. in vitro: ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC(50) = 8 nM) and VEGF-R2 tyrosine phosphorylation in vitro[1]. The VEGF-induced elevation of LpA/Vi was blocked by the selective VEGF-R2 inhibitor ZM323881 [3]. Stimulation of FTC133 cells with exogenous VEGF enhanced ID3 expression, which could be abrogated by the inhibitor ZM323881 [4]. in vivo: VEGF-A-mediated increases in vascular permeability in perfused mesenteric microvessels in vivo were reversibly abolished |
| 别名 | Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-, hydrochloride (1:1);Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-, hydrochloride (1:1) |
ZM 323881 盐酸盐
ZM 323881 HCl （订货以英文为准）
编号：Z129761
CAS号：193000-39-4
分子式：C22H19CLFN3O2
分子量：411.86
| 产品名称 | ZM 323881 HCl |
| 中文名称 | ZM 323881 盐酸盐 |
| CAS号 | 193000-39-4 |
| 分子式（M.F.） | C22H19CLFN3O2 |
| 分子量（M.W.） | 411.86 |
| 储存条件 | -20°C储存 |
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