| 折光率 | 1.66 |
| 溶解性 | DMSO 92 mg/mL Water <1 mg/mL Ethanol 92 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.7300 |
| 应用 | An antineoplastic selective MEK inhibitor |
| 产品介绍 | AZD8330(ARRY-424704; ARRY-704)是非ATP竞争性MEK 1/2抑制剂，IC50为7 nM。 |
| 备注 | AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. |
| 生化机理 | AZD8330 potently and strongly inhibits MEK 1/2. AZD8330 has no inhibitory activity against over 200 other kinases including at concentrations up to 10 μM. AZD8330 demonstrates sub-nanomolar potency in mechanistic (pERK) and low to sub-nanomolar potency in functional (proliferation) assays in MEK 1/2 inhibitor sensitive cell lines. |
| 别名 | ARRY-424704; ARRY424704;ARRY704; AZD8330;2-(2-fluoro-4-iodophenylamino)-n-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide; AZD-8330; ARRY-704;2-(2-氟-4-碘苯氨基)-N-(2-羟基乙氧基)-1,5-二甲基-6-氧代-1,6-二氢吡啶-3-甲酰胺; |
AZD8330,变构MEK抑制剂
AZD8330 （订货以英文为准）
编号：A127453
CAS号：869357-68-6
分子式：C16H17FIN3O4
分子量：461.23
| 产品名称 | AZD8330 |
| 中文名称 | AZD8330,变构MEK抑制剂 |
| CAS号 | 869357-68-6 |
| 分子式（M.F.） | C16H17FIN3O4 |
| 分子量（M.W.） | 461.23 |
| 储存条件 | -20°C储存 |
| Reaxys-RN | 1885770 |
| 信号词 | Danger |
| 危害声明 | H315-H319-H335-H360 |
| 警示性声明 | P201-P261-P305 + P351 + P338-P308 + P313 |
| 个人防护设备 | Eyeshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges |
| RTECS | VH6440000 |
| WGK德国 | 3 |
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