| 熔点 | 85°C |
| 旋光率 | 33 ° (C=1, EtOH) |
| 存贮条件 | 贮存温度2-8℃ |
| 密度 | 1.1600 |
| 应用 | 抗菌消炎药，用于慢性宫颈炎、菌痢、肠炎等 |
| 生化机理 | Description:IC50 Value: 540 μg/ml (inhibit gastric cancer cell line MNK45, MTT) [1]Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and ?-receptor agonist.in vitro: MTT assay showed that the matrine was able to inhibit gastric cancer cell line MNK45 in a dose-dependent manner. The concentration required for 50% inhibition (IC50) was found to be 540 μg/ml. This anti-tumor function was achieved through modulation of the NF-κB, XIAP, CIAP, and p-ERK proteins expression in cell line MNK45. Matrine induces apoptosis of human NSCLC cells with anti-apoptotic factors inhibited and dependent on caspase activity. In addition, we found that matrine increases the phosphorylation of p38 but not its total protein, and inhibition of the p38 pathway with SB202190 partially prevents matrine-induced apoptosis. Furthermore, matrine generates reactive oxygen species (ROS) in a dose- and time-dependent manner, which is reversed by pretreatment with N-acetyl-L-cysteine (NAC) [2].in vivo: Oral administration of matrine (200, 100 and 50 mg/kg) significantly attenuated isoproterenol-induced cardiac necrosis and left ventricular dysfunction [3]. high dose of matrine significantly reduced the mortality rate of mice with LPS administration. Treatment with matrine improved LPS-induced lung histopathologic changes, alleviated pulmonary edema and lung vascular leak, inhibited MPO and MDA activity,and reduced the production of inflammatory mediators including TNF-α, IL-6 and HMGB1 [4].Toxicity: N/AClinical trial: N/A |
| 别名 | 苦参碱Matridin-15-one Sophocarpidine |
苦参碱
Matrine （订货以英文为准）
编号：M109803
CAS号：519-02-8
分子式：C15H24N2O
分子量：248.36
| 产品名称 | Matrine |
| 中文名称 | 苦参碱 |
| CAS号 | 519-02-8 |
| MDL编码 | MFCD00210527 |
| 分子式（M.F.） | C15H24N2O |
| 分子量（M.W.） | 248.36 |
| 储存条件 | 2-8°C储存 |
| Merck Index | 4331 |
| 个人防护设备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
| RTECS | LW5180000 |
| WGK德国 | 2 |
| 安全声明（欧洲） | S24/25 |
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