| 溶解性 | DMSO mg/mL Water mg/mL Ethanol mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | {2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid |
| 备注 | GW501516 is a potent and highly selective PPARβ/δ agonist, with EC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ. Phase 4. |
| 生化机理 | GW501516 (GW1516 or GSK-516) is a drug that acts as a PPARδ modulator. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue, and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It has been proposed as a potential treatment for obesity and related conditions, especially when used in conjunction with a synergistic compound AICAR, as the combination has been shown to significantly increase exercise endurance in animal studies. |
| 别名 | GW1516, GSK-516, GW-501516;2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy)acetic acid;GW1516, GSK-516, GW-501516;2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy)acetic acid |
GW501516,PPARδ激动剂
GW501516 （订货以英文为准）
编号：G129772
CAS号：317318-70-0
分子式：C21H18F3NO3S2
分子量：453.50
| 产品名称 | GW501516 |
| 中文名称 | GW501516,PPARδ激动剂 |
| CAS号 | 317318-70-0 |
| 分子式（M.F.） | C21H18F3NO3S2 |
| 分子量（M.W.） | 453.50 |
| 储存条件 | -20°C储存 |
| Reaxys-RN | 7694998 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs06.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H301-H351-H361-H373-H412 |
| 警示性声明 | P273-P281-P301 + P310 |
| RTECS | UV9145000 |
| WGK德国 | 3 |
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