| 熔点 | 109-111° C |
| 折光率 | 1.62 |
| 溶解性 | DMSO 21 mg/mL Water <1 mg/mL Ethanol 20 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death. |
| 产品介绍 | SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
| 备注 | SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
| 生化机理 | SANT-1 inhibited Sonic hedgehog signaling and induced apoptosis via Ras/NF-κB pathway in glioblastoma cells. SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency. |
| 别名 | (E)-N-(4-苄基-1-哌嗪基)-1-(3,5-二甲基-1-苯基-1H-吡唑-4-基)甲亚胺;(E)-N-(4-Benzyl-1-piperazinyl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine;(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine |
SANT-1,平滑刺猬信号拮抗剂
SANT-1 （订货以英文为准）
编号：S129830
CAS号：304909-07-7
分子式：C23H27N5
分子量：373.49
| 产品名称 | SANT-1 |
| 中文名称 | SANT-1,平滑刺猬信号拮抗剂 |
| CAS号 | 304909-07-7 |
| 分子式（M.F.） | C23H27N5 |
| 分子量（M.W.） | 373.49 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Warning |
| 危害声明 | H302-H351 |
| 警示性声明 | P281 |
| RTECS | UX9590000 |
| WGK德国 | 3 |
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