| 熔点 | 138°C |
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in methanol ( ), water (<1 mg/ml), chloroform, DMSO (81 mg/ml), and ethanol (3 mg/ml). |
| 存贮条件 | 储存温度 -20°C |
| 应用 | An antioxidant and anti-inflammatory that Inhibits the phosphorylation of MEK. |
| 产品介绍 | Nobiletin is a flavanoid with antioxidant and anti-inflammatory properties found in the rind of tangerines. The compound has been observed to inhibit the phosphorylation of MEK (mitogen-activated protein kinase). Nobiletin has also been documented to suppress the expression of MMP-1 (matrix metalloproteinases), MMP-3 and MMP-9 that are involved in the breakdown of the extracellular matrix during tumor metastasis. In vitro studies of Nobiletin on varying cancer cell lines and on the chick egg has shown the anti-angiogenic effects of Nobiletin through down regulation of ERK 1, ERK 2 and c-Jun N-terminal kinase, and transcriptional factors c-Jun and Stat3. The compound also suppressed proliferation, migration and tube formation on matrigel of HUVEC cells stimulated with growth supplement. Nobiletin has demonstrated to attenuate NF-κB transcriptional activation, NO and PGE2 production, NOS2 (inducible nitric oxide synthase) and Cox-2 (cyclooxygenase-2) expression. |
| 生化机理 | Nobiletin suppresses the expression of matrix metalloproteinases 1, 3 and 9, which participate in the break down of the extracellular matrix during tumor metastasis. Nobiletin is also involved in the increased expression of tissue inhibitor of matrix metalloproteinase 1 further preventing extracellular matrix degradation during tumor invasion. This bioflavonoid is believed to achieve both of these functions by disrupting the signal transduction pathway of Ras-Raf-MEK. |
| 别名 | 3',4',5,6,7,8-六甲氧基黄酮;蜜橘黄素2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one;3′,4′,5,6,7,8-Hexamethoxyflavone |
川皮苷
Nobiletin （订货以英文为准）
编号：N130078
CAS号：478-01-3
分子式：C21H22O8
分子量：402.39
| 产品名称 | Nobiletin |
| 中文名称 | 川皮苷 |
| CAS号 | 478-01-3 |
| MDL编码 | MFCD03273560 |
| 分子式（M.F.） | C21H22O8 |
| 分子量（M.W.） | 402.39 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs02.jpg,https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg,https://www.aladdin-e.com/images/ghs/ghs09.jpg |
| 信号词 | Danger |
| 危害声明 | H225,H304,H315,H336,H410 |
| 警示性声明 | P210,P261,P273,P301+P310,P331,P501 |
| 个人防护设备 | Eyeshields,Faceshields,full-face respirator (US),Gloves,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter |
| WGK德国 | 1 |
| 闪点（摄氏） | 113 °C |
| 风险声明 (欧洲) | 11,38,50/53,65,67 |
| 安全声明（欧洲） | S23;S24/25 |
| 危害码（欧洲） | F,Xn,N |
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