| 溶解性 | DMSO 70 mg/mL Water <1 mg/mL Ethanol 7 mg/mL |
| 存贮条件 | 储存温度2-8℃ |
| 产品介绍 | IPA-3 |
| 备注 | IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6). |
| 生化机理 | Description:IC50 Value: 2.5uM; 1.92 ± 0.2 μM( Dissociation constant) [1]IPA-3 is a novel small-molecule PAK inhibitor. IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.in vitro: Saturable binding of IPA-3 to full-length Pak1 was observed with an apparent dissociation constant of 1.92 ± 0.2 μM, consistent with the reported IC50 of 2.5 μM. IPA-3 bound the isolated RD with an even higher apparent affinity (0.1 ± 0.01 μM) whereas the kinase domain showed a weaker interaction. IPA-3 blocks activation of PAK2 at Ser192/197 that antagonises PAK's interaction with Pix. Accordingly, Pix-mediated Rac1 activation is decreased in IPA-3 treated schwannoma cells, indicating that PAK acts upstream of Rac [2]. In K562 cells, both chorein silencing and PAK1 inhibition with IPA-3 decreased phosphorylation of Bad, a Bcl2-associated protein, promoting apoptosis by forming |
| 别名 | 2-Naphthalenol, 1,1'-dithiobis-;2-Naphthalenol, 1,1'-dithiobis- |
二(2-羟基-1-萘基)二硫醚
IPA-3 （订货以英文为准）
编号：I125982
CAS号：42521-82-4
分子式：C20H14O2S2
分子量：350.45
| 产品名称 | IPA-3 |
| 中文名称 | 二(2-羟基-1-萘基)二硫醚 |
| CAS号 | 42521-82-4 |
| MDL编码 | MFCD00388917 |
| 分子式（M.F.） | C20H14O2S2 |
| 分子量（M.W.） | 350.45 |
| 储存条件 | 2-8°C储存;避光 |
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