AZD4547,新型FGFR抑制剂

AZD4547 (订货以英文为准)

编号:A127209
CAS号:1035270-39-3
分子式:C26H33N5O3
分子量:463.57
货号 品牌 包装 目录价 您的价格 库存 数量 购买
A127209-10mg 阿拉丁 10mg ¥305.90
A127209-50mg 阿拉丁 50mg ¥958.90
A127209-100mg 阿拉丁 100mg ¥1462.90
A127209-25mg 阿拉丁 25mg ¥576.90
A127209-5mg 阿拉丁 5mg ¥184.90
产品名称 AZD4547
中文名称 AZD4547,新型FGFR抑制剂
CAS号 1035270-39-3
分子式(M.F.) C26H33N5O3
分子量(M.W.) 463.57
储存条件 -20°C储存
溶解性DMSO 92 mg/mL (198.45 mM);Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM);
存贮条件储存温度-20°C
应用A novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3.
产品介绍AZD4547是一种新型选择性的FGFR抑制剂,靶向作用于FGFR1/2/3,IC50为0.2 nM/2.5 nM/1.8 nM,对FGFR4, VEGFR2(KDR)具有微弱的作用活性,对IGFR, CDK2和p38几乎没有作用活性。Phase 2/3。
备注AZD4547 is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 1/2.
生化机理AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3. AZD4547 treatment potently inhibits FGFR and MAPK phosphorylation in tumor cell lines in a dose-dependent manner.
别名rel-N-[5-[2-(3,5-二甲氧基苯基)乙基]-1H-吡唑-3-基]-4-[(3R,5S)-3,5-二甲基-1-哌嗪基]苯甲酰胺;AZD 4547;AZD-4547;N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide;rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide
标识符号https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Warning
危害声明H315-H319-H335
警示性声明P261-P305 + P351 + P338
个人防护设备dust mask type N95 (US), Eyeshields, Gloves
WGK德国3
搜索质检报告(COA)
搜索MSDS
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