SB505124,竞争性ALK5抑制剂

SB505124 (订货以英文为准)

编号:S126125
CAS号:694433-59-5
分子式:C20H21N3O2
分子量:335.40
货号 品牌 包装 目录价 您的价格 库存 数量 购买
S126125-50mg 阿拉丁 50mg ¥2244.90
S126125-10mg 阿拉丁 10mg ¥1016.90
产品名称 SB505124
中文名称 SB505124,竞争性ALK5抑制剂
CAS号 694433-59-5
分子式(M.F.) C20H21N3O2
分子量(M.W.) 335.40
储存条件 -20°C储存
溶解性DMSO 67 mg/mL Water <1 mg/mL Ethanol 67 mg/mL
存贮条件储存温度-20°C
应用An inhibitor of Activin receptor-like kinase 5
产品介绍SB505124是一种选择性TGFβR抑制剂,作用于ALK4和ALK5,无细胞试验中IC50分别为129 nM和47 nM,也抑制ALK7,但不抑制ALK1,2,3或6。
备注SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.
生化机理SB-505124 is an inhibitor of activin receptor-like kinase (ALK-5). SB-505124 is demonstrated to suppress the action of transforming growth factor-B (TGF-B) both in vitro and in vivo.
别名2-[4-(1,3-苯并二恶茂-5-基)-2-(叔丁基)-1H-咪唑-5-基]-6-甲基吡啶;SB505124;SB 505124;SB505124;2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine
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