| 溶解性 | DMSO : 94 mg/mL (209.34 mM; Need ultrasonic and warming) |
| 存贮条件 | 储存温度-20°C |
| 应用 | An H460 and HT29 cell growth inhibitor |
| 产品介绍 | Evofosfamide (TH-302) 是一种缺氧 (hypoxia) 激活前药，缺氧 (N2) 和常氧 (21% O2) 环境下，IC50 分别为 10 μM 和 1000 μM。 |
| 备注 | TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 me |
| 生化机理 | TH-302 is a newly developed antineoplastic drug which represents a potential new class of tumor selective hypoxia-activated prodrugs (HAPs). |
| 别名 | TH 302;TH302;N,N'-双(2-溴乙基)二氨基膦酸 (1-甲基-2-硝基-1H-咪唑-5-基)甲酯;TH 302;TH302;Evofosfamide;N,N′-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester |
TH-302,低氧激活的前体药物
TH-302 （订货以英文为准）
编号：T126300
CAS号：918633-87-1
分子式：C9H16BR2N5O4P
分子量：449.04
| 产品名称 | TH-302 |
| 中文名称 | TH-302,低氧激活的前体药物 |
| CAS号 | 918633-87-1 |
| 分子式（M.F.） | C9H16BR2N5O4P |
| 分子量（M.W.） | 449.04 |
| 储存条件 | -20°C储存 |
| WGK德国 | 3 |
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